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Total 17508 results found since Jan 2013.
Mesenchymal Stem Cells as an Adjuvant Tool to Induce Regeneration and Repair in Marginal Renal Allografts
AbstractPurpose of ReviewMesenchymal stem cells (MSC) have been largely studied for more than three decades and have been proposed to treat a myriad of clinical conditions in dozens of clinical trials.Recent FindingsThey have become popular in transplant medicine due to their immunomodulatory properties with promising results. In the past decade, however, they have also been tested in the setting of organ preservation in reason of their ability to induce regeneration and repair in damaged tissues.SummaryThis manuscript reviews the worldwide experience relative to the use of MSC and their by-products, as therapeutic tool to...
Source: Current Transplantation Reports - September 22, 2023 Category: Transplant Surgery Source Type: research
Can the Acetabular Labrum Be Reconstructed With a Meniscal Allograft? An In Vivo Pig Model
CONCLUSION: In a pig model, lateral meniscus allografts fully filled labral defects in labral reconstruction. Regeneration of a fibrocartilage transition zone at the graft-acetabulum interface was observed at 24 weeks.CLINICAL RELEVANCE: The use of an autograft meniscus for labral reconstruction may be a viable option when labral tears are deemed irreparable. Before its clinical implementation, it is imperative to conduct a comparative study involving tendon grafts, which are extensively used in current clinical practice.PMID:37732715 | DOI:10.1097/CORR.0000000000002860
Source: Clinical Orthopaedics and Related Research - September 21, 2023 Category: Orthopaedics Authors: Maihemuti Maimaitimin Fan Yang Hongjie Huang Yingfang Ao Jianquan Wang Source Type: research
Therapeutic benefits of nitric oxide in lung transplantation
Biomed Pharmacother. 2023 Sep 19;167:115549. doi: 10.1016/j.biopha.2023.115549. Online ahead of print.ABSTRACTLung transplantation is an evolutionary procedure from its experimental origin in the twentieth century and is now recognized as an established and routine life-saving intervention for a variety of end-stage pulmonary diseases refractory to medical management. Despite the success and continuous refinement in lung transplantation techniques, the widespread application of this important life-saving intervention is severely hampered by poor allograft quality offered from donors-after-brain-death. This has necessitated...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: George J Dugbartey Source Type: research
cGAS –STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes
Transplantation is an important life-saving therapeutic choice for patients with organ or tissue failure once all other treatment options are exhausted. However, most allografts become damaged over an extended period, and post-transplantation survival is limited. Ischemia reperfusion injury (IRI) tends to be associated with a poor prognosis; resultant severe primary graft dysfunction is the main cause of transplant failure. Targeting the cGAS–STING pathway has recently been shown to be an effective approach for improving transplantation outcomes, when activated or inhibited cGAS–STING pathway, IRI can be alleviated by ...
Source: Frontiers in Immunology - September 21, 2023 Category: Allergy & Immunology Source Type: research
Pretransplant BKV-IgG serostatus and BKV-specific ELISPOT assays to predict BKV infection after kidney transplantation
DiscussionOur study highlights the importance of pretransplant BKV-IgG serostatus and BKV-specific CMI in predicting posttransplant BKV infection in KTRs. The combination of high donor BKV-IgG, low recipient BKV-IgG, and low total BKV-ELISPOT results predicted BK viremia after KT. Pretransplant identification of patients at highrisk for BK viremia could enable timely interventions and improve clinical outcomes of KTRs.
Source: Frontiers in Immunology - September 21, 2023 Category: Allergy & Immunology Source Type: research
Linking donor-specific antibody generation with natural killer cells in antibody-mediated kidney graft rejection
Natural killer (NK) cell infiltration of kidney allografts is a distinguishing feature of antibody-mediated rejection. Bailly et  al. identify a distinct population of cytotoxic CD160+ interleukin-21 receptor+ CD56dimCD16bright NK cells that are uniquely found in the peripheral blood of donor-specific antibody–positive kidney transplant recipients and are present in kidney allografts with active antibody-mediated rejection . This population is implicated in a T follicular helper/interleukin-21/NK cell axis that links donor-specific antibody generation with graft-infiltrating NK cells in antibody-mediated rejection.
Source: Kidney International - September 20, 2023 Category: Urology & Nephrology Authors: Griffith B. Perkins, Robert L. Fairchild Tags: Commentary Source Type: research
Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation
This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVE...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Francisco Villalba-L ópez David Garc Ãa-Bernal Sandra V Mateo Daniel Vidal-Correoso Marta Jover-Aguilar Felipe Alconchel Laura Mart Ãnez-Alarcón V Ãctor López-López Antonio R Ãos-Zambudio Pedro Cascales Jos é A Pons Pablo Ram Ãrez Pablo Pelegr à Source Type: research
Low-MFI (median fluorescence intensity) pre-transplant DSA (donor specific antibodies) leading to anamnestic antibody mediated rejection in live-related donor kidney transplantation
We present two cases of live-related donor kidney transplants (LDKTs) with low-MFI pre-transplant DSA values who experienced an early acute antibody-mediated rejection (ABMR) as a result of an anamnestic antibody response by DSA against HLA class II antibodies. These results were confirmed by retesting of both pre-transplant and post-transplant archived sera from patients as well as freshly obtained donor cells. Our examples indicate a possible ABMR in patients with low MFI pre-transplant DSA. Reclassification of low vs. high-risk may be appropriate for some patients with low-MFI DSA."PMID:37730185 | DOI:10.1016/j.trim.2023.101931
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Rajni Chauhan Aseem Kumar Tiwari Geet Aggarwal L Gowri Suresh Mohit Kumar Shyam Bihari Bansal Source Type: research
Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation
This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVE...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Francisco Villalba-L ópez David Garc Ãa-Bernal Sandra V Mateo Daniel Vidal-Correoso Marta Jover-Aguilar Felipe Alconchel Laura Mart Ãnez-Alarcón V Ãctor López-López Antonio R Ãos-Zambudio Pedro Cascales Jos é A Pons Pablo Ram Ãrez Pablo Pelegr à Source Type: research
Low-MFI (median fluorescence intensity) pre-transplant DSA (donor specific antibodies) leading to anamnestic antibody mediated rejection in live-related donor kidney transplantation
We present two cases of live-related donor kidney transplants (LDKTs) with low-MFI pre-transplant DSA values who experienced an early acute antibody-mediated rejection (ABMR) as a result of an anamnestic antibody response by DSA against HLA class II antibodies. These results were confirmed by retesting of both pre-transplant and post-transplant archived sera from patients as well as freshly obtained donor cells. Our examples indicate a possible ABMR in patients with low MFI pre-transplant DSA. Reclassification of low vs. high-risk may be appropriate for some patients with low-MFI DSA."PMID:37730185 | DOI:10.1016/j.trim.2023.101931
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Rajni Chauhan Aseem Kumar Tiwari Geet Aggarwal L Gowri Suresh Mohit Kumar Shyam Bihari Bansal Source Type: research
Validation of orthopedic allograft preparation process: a new application of media fill test
This study describe the design and execution of an adapted Media Fill Test (MFT) to demonstrate aseptic thawing and washing of allografts. For this specific and innovative setting, to better simulate the actual processing steps, a surrogate system was developed to simulate the tendon allograft. The aseptic technique of four operators was assessed and an initial performance validation and the first revalidation were described. All MFT were completed successfully, with no observation of turbidity. The readapted MFT shown in this study can provide insight into this innovative and growing field to other health professionals wh...
Source: Cell and Tissue Banking - September 20, 2023 Category: Stem Cells Source Type: research
Larval therapy vs conventional silver dressings for full-thickness burns: a randomized controlled trial
CONCLUSIONS: Our findings revealed that MDT has a favorable superiority over conventional regimen for the treatment of grade-III burns, and thus further clinical trials with larger sample size are warranted to confirm these results.PMID:37726738 | DOI:10.1186/s12916-023-03063-7
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Jasem Gaffari Kamran Akbarzadeh Mozhgan Baniardalani Reza Hosseini Safdar Masoumi Zahra Sadat Amiri Razieh Shabani Kordshouli Javad Rafinejad Mostafa Dahmardehei Source Type: research
Operating microscope-assisted reconstructive strategy for peri-implantitis: A case series report
CONCLUSIONS: Preliminary data suggest encouraging outcomes after the microsurgical approach following biological as well as biomechanical principles for peri-implant defect reconstruction.PMID:37724638 | DOI:10.1002/cap.10265
Source: Adv Data - September 19, 2023 Category: Epidemiology Authors: Yi-Chen Chiang Benyapha Sirinirund Amanda Rodriguez Diego Velasquez Hsun-Liang Chan Source Type: research
A collagen-binding SIRP αFc fusion protein for targeted cancer immunotherapy
Int Immunopharmacol. 2023 Sep 16;124(Pt B):110951. doi: 10.1016/j.intimp.2023.110951. Online ahead of print.ABSTRACTCollagen is abundant but exposed in tumor due to the abnormal tumor blood vessels, thus is considered as a tumor-specific target. The A3 domain of von Willebrand factor (vWF A3) is a kind of collagen-binding domain (CBD) which could bind collagen specifically. Previously we reported a chemosynthetic CBD-SIRPαFc conjugate, which could block CD47 and derived tumor-targeting ability by CBD. CBD-SIRPαFc conjugate represented improved anti-tumor efficacy with increased MHC II+ M1 macrophages, but the uncertain c...
Source: International Immunopharmacology - September 18, 2023 Category: Allergy & Immunology Authors: Jiayang Liu Tongyang Xu Danjie Pan Jiajun Fan Yuan Fu Xiting Huang Weili Zhao Xiaochun Dong Shaohui Zhang Kudelaidi Kuerban Xuan Huang Songna Wang Huaning Chen Yunpeng He Yi Zhun Zhu Congjun Wang Li Ye Source Type: research
Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary non-function of fatty liver allografts
Transl Res. 2023 Sep 16:S1931-5244(23)00146-9. doi: 10.1016/j.trsl.2023.09.006. Online ahead of print.ABSTRACTOrthotopic liver transplantation (OLT) is a lifesaving procedure. However, grafts may fail due to primary non-function (PNF). In the past, we demonstrated PNFs to be mainly associated with fatty allografts, and given its unpredictable nature, the development of a disease model is urgently needed. In an effort to investigate mechanism of fatty-allograft associated PNFs, we induced fatty liver disease in donor animals by feeding rats a diet deficient in methionine and choline (MCD). We performed OLT with allografts o...
Source: Translational Research : the journal of laboratory and clinical medicine - September 18, 2023 Category: Laboratory Medicine Authors: Ulf Kulik Caroline Moesta Reinhard Spanel J ürgen Borlak Source Type: research
